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Appearances in film and television

  • The film American Graffiti features the song being played on the Wolfman Jack Show, performed by The Cleftones
  • The film The Competition features a humorous section where the leading competitors suddenly burst out playing "Heart and Soul" while practicing the piano
  • The film Big features the piece being played on a giant electronic keyboard.
  • The film Stuart Little features the song, played and sung by Hugh Laurie and Geena Davis.
  • The band Liquid Tension Experiment plays a part of the song at the end of "Universal Mind" on their Liquid Tension Experiment album.
  • In Star Trek: Voyager, Season 5 Episode 18 "Course Oblivion", Harry plays the piece with his Clarinet just before B'Elanna Torres enters the room for her wedding with Tom Paris.
  • The film Superman Returns also features the piece being played on a grand piano by Lois Lane's 5 year old son Jason in Lex Luthor's yacht.
  • In episode 20 of the TV series, Lost, the song is played in a flashback by Jack Shepherd and his new wife.
  • In episode 20, season 5 of the TV series, Frasier, the song is sung by Niles and Daphne while chopping vegetables in Niles' kitchen.
  • In an episode of the TV series, The New Leave It to Beaver, one of the children sings the song in the hopes of distracting the adults from discovering a mistake he made.
  • In episode 6 of the TV series Raines, Michael Raines plays "Heart and Soul" amateurishly with a murdered 10-year-old girl that he imagines. It's shown that while he plays one part, he hums the other.
  • In episode 17, season 5 of Family Guy, the tune is played by Stewie to mock Peter, a parody of the scene in the film Amadeus where Mozart mocks Salieri.
  • In episode 17, season 9 of Family Guy, played by Stewie and Brian before the Big Bang when there where no laws of physics.
  • Steve Goodman's song "Penny Evans", referring to American draftees killed in Vietnam, mentions "fifty thousand 'Heart and Souls' being played with just one hand."
  • The song is briefly played in the First Communion ceremony at the beginning of The Godfather, Part II.
  • In 'Cro-Magnon', Season 1 Episode 12 of Ally McBeal, the song is played by Ally and her well-endowed date.
  • The song is featured in the musical revue Forever Plaid.
  • In the season 3 finale of Ellen, the song was played and sung at Paige's wedding.
  • In episode 25, season 9 of The Simpsons, the song is briefly played for about a bar and a half featuring on the alternate Casablanca ending that Bart found.
  • In The Simpsons season 20, the episode, "Gone Maggie Gone", Lisa plays it on the organ to unlock a clue.
  • In season six of Scrubs, Kim Briggs and J.D. play the piece on a piano, J.D. playing the left-hand part, Kim playing the right-hand part with her nose. This offends the woman in the house, who has no thumbs.
  • In the The Heart of Me original soundtrack Helena Bonham Carter performs this song, but it is not in included in the movie.
  • In the episode "Imaginary Friend" of The Nanny, Maggie plays "Heart and Soul" upon request of Brighton.
  • The film 127 Hours features the song in one of the flashbacks.
  • The song was prominently featured in episode 15 of the TV series Now and Again.
  • In the film Racing with the Moon it is played by Sean Penn and Elizabeth McGovern.
  • In a scene in the To Be or Not to Be remake, Anna Bronski (Anne Bancroft) is serenading a **** official on the piano. Just as she reaches the end of one song, she launches into "Heart and Soul".
  • In the Apple iPad Mini advertisement in 2012, where an iPad mini is shown playing a duet with an iPad on the piano in Apple's GarageBand app.
  • In the film "Bicentennial Man" Robin Williams plays the song with the little girl and again when she is an adult.